On a dark, late night in New York City, Ryu is chased and attacked by assassins. After disposing of them, he finds an I.D. card for the Friedman Company. The next day, it is announced that Dr. Ned Friedman has discovered a cure for cancer. But after providing no information at his press conference, a reporter named Sarah decides to investigate with the help of her friends Robert and Jeff. When passing by Dr. Friedman's house one day, Ryu hears the voice of a young girl calling for help. When Sarah and her entourage investigate the house as well, they run into their colleague, Ryu. Upon that, they discover Dr. Friedman has been conducting experiments on live humans using biotechnology, and that it may have something to do with the power of the Evil Gods, whom Ryu had defeated in the past. But when Ryu's friend, Irene, is kidnapped, he must dawn his role as a Dragon Ninja once again to defeat this new enemy and save her.